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Space Science Digital > Blog > Technology > Microfluidic setup for the continuous production of multifunctional nanoparticles
Technology

Microfluidic setup for the continuous production of multifunctional nanoparticles

By Aimee Daly March 22, 2023 3 Min Read
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Synthesis of core cross-linked polymeric micelles in a continuous flow process. (A) Amphiphilic thiol-reactive pSar-b-pCys(SO2Et) polypept(o)ides are assembled to polymeric micelles via solvent switch followed by cross-linking by chemo-selective disulfide bond formation with dihydrolipoic acid hydrazide. (B) Photo of the continuous flow setup (C) Chart of the continuous flow process. Reagent mixing by slit interdigital micromixers operated by HPLC pumps, and online particle purification by tangential flow filtration (MWCO, 30 kDa; regenerated cellulose membrane). (D) Schematic illustration of the slit interdigital micromixer used for self-assembly and cross-linking (SIMM-V2). Credit: Advanced Materials (2023). DOI: 10.1002/adma.202210704

The synthesis of multifunctional nanoparticles is commonly a complex endeavor and hampers the clinical translation of effective nanomedicines. In their most recent work, Matthias Barz and coworkers present a microfluidic setup for the continuous production of drug-loaded core cross-linked polymeric micelles (CCPMs) in a single precisely controlled process. The study is published in the journal Advanced Materials.

The project was performed in collaboration with the Max Planck Institute for Polymer Research, the University of Oslo, and the Fraunhofer Institute for Microengineering and Microsystems (IMM) in Mainz. While Kaloian Koynov and his team helped to characterize the formed CCPMs in biological fluids, the team of the IMM lead by Michael Maskos contributed their immense expertise on microfluidics to develop this unique setup combining two slit interdigital micromixers and a tangential flow filtration unit.

The system enables the controlled formation of micelles in mixer one, the precise core cross-linking in the second mixer, followed by the purification via tangential flow filtration, which removes remaining crosslinkers, unimers, and trances of organic solvents to yield purified functional CCPMs. Combined with functional (prodrug-containing) cross-linkers the process enables the continuous production of drug-loaded CCPMs under specifically controlled conditions, which substantially eases library synthesis, scale-up, certified production, and the clinical translation of lead candidates.

In a first study, the synthesized Paclitaxel-containing CCPMs showed therapeutic efficiency in a B16F10 melanoma model and outperformed the approved Paclitaxel formulation Abraxane, which underlines the therapeutic potential of CCPMs based on polypept(o)ides and microfluidic systems.

More information:
Tobias A. Bauer et al, Complex Structures Made Simple—Continuous Flow Production of Core Cross‐Linked Polymeric Micelles for Paclitaxel Pro‐Drug‐Delivery, Advanced Materials (2023). DOI: 10.1002/adma.202210704

Provided by
Leiden University


Citation:
Microfluidic setup for the continuous production of multifunctional nanoparticles (2023, March 22)
retrieved 22 March 2023
from https://phys.org/news/2023-03-microfluidic-setup-production-multifunctional-nanoparticles.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



TAGGED: continuous, Microfluidic, multifunctional, nanoparticles, production, setup

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