By using this site, you agree to the Privacy Policy and Terms of Use.
Accept

Science, Space & Technology

Space Science Digital
Contact
Search
  • Home
  • Environment

    Watch DART asteroid impact in Hubble movie

    March 6, 2023

    Terminator zones and the search for life

    March 28, 2023

    Webb takes a “deep field” look at the Pandora Cluster, a vast galactic smash up

    April 15, 2023

    Webb finds water vapor near star with exoplanet

    May 7, 2023
  • Space Flight

    SpaceX launches Inmarsat I-6 F2 on 12th mission of 2023

    February 17, 2023

    China reveals lunar lander, launches satellites, and conducts a spacewalk

    March 10, 2023

    Spacesuit prototype revealed for Artemis 3 Moon landing

    March 15, 2023

    Psyche and JUICE: Spacecraft are heading to a metal asteroid and Jupiter’s moons in 2023

    December 28, 2022
  • Cosmology

    Giant young galaxies shake up our understanding of the early universe

    February 23, 2023

    Rising star in astronomy: Wen-Fai Fong

    February 6, 2023

    Astronomy magazine seeks Associate Editor and Staff Writer

    March 14, 2023

    Next-gen Event Horizon Telescope aims to get videos of black holes

    March 20, 2023
  • Latest
  • About Us
Reading: Light-induced acceleration of intracellular delivery
Share
Aa
Space Science DigitalSpace Science Digital
  • Environment
  • Space Flight
  • Cosmology
  • Technology
Search
  • Home
  • Categories
    • Environment
    • Technology
    • Cosmology
    • Space Flight
  • More Foxiz
    • Blog Index
    • Forums
    • Complaint
    • Sitemap
Follow US
© 2023 Space Science Digital. All Rights Reserved.
Space Science Digital > Blog > Technology > Light-induced acceleration of intracellular delivery
Technology

Light-induced acceleration of intracellular delivery

By Aimee Daly March 6, 2023 4 Min Read
Share


Light-induced accelerating system to increase the concentration of biofunctional molecules around targeted cells and their cytosolic delivery. Credit: Ikuhiko Nakase, and Takuya Iida, OMU

Cell membranes are barriers that maintain cellular homeostasis, and the intracellular delivery of biologically functional molecules, including peptides, proteins, and nucleic acids to manipulate cellular functions. Conventional intracellular uptake processes require high concentrations of biofunctional molecules with low permeability to pass through the cell membrane.

This results in low drug activity because the probability of the biofunctional molecules entering target cells and their organelles is low. In addition, many drugs damage healthy cells as well as the cells that are supposed to be targeted due to poor selectivity, making it necessary to develop technology that can increase drugs’ selectivity so that they enter targeted cells with high efficiency.

A research group led by Professor Ikuhiko Nakase (Assistant Director) and Professor Takuya Iida (Director) of the Research Institute for Light-induced Acceleration System (RILACS) at Osaka Metropolitan University used light-induced convection with the aid of superradiance to achieve enhanced permeability of the cell membrane, by locally concentrating biofunctional molecules, including cell-penetrating peptides (CPPs). The light-induced system was capable of effective drug delivery, even at concentrations as low as 1 pmol/L.

To induce photothermal assembly around live cells in a cell culture medium, an infrared laser using a 10x objective was focused for one-hundred seconds on the bottom of a glass dish densely coated with gold nanoparticles; the laser’s wavelength is hardly absorbed by living organisms and does not cause damage but can generate heat and a photothermal flow. Molecules were concentrated near a bubble generated by the laser heat, which was located approximately 100 µm away from the target cells on the substrate.

Using this system, the group found that around the laser irradiation point, mitochondrial structures near the photo-induced bubbles were efficiently stained even at a concentration 0.1% of that of conventional methods. Furthermore, the light-induced acceleration succeeded in inducing apoptosis using CPPs at a concentration of 1% of that of conventional methods, resulting in extremely efficient and selective cellular uptake that resulted in the destruction of targeted cancer cells.

“Developing technologies that can selectively introduce biofunctional molecules into targeted cells is important, not only for basic research but also in clinical practice. We expect these results will significantly reduce the concentration of drugs needed to perform cell testing. Because new drugs are often expensive to manufacture, this will lower costs—and speed up drug discovery. Furthermore, we will apply these results to medical technologies that can contribute to cancer diagnosis and treatment and strive to make this technology useable in human healthcare,” concluded Professor Nakase and Professor Iida in a joint statement.

The findings are published in the journal Nano Letters.

More information:
Ikuhiko Nakase et al, Light-Induced Condensation of Biofunctional Molecules around Targeted Living Cells to Accelerate Cytosolic Delivery, Nano Letters (2022). DOI: 10.1021/acs.nanolett.2c02437

Provided by
Osaka Metropolitan University

Citation:
Light-induced acceleration of intracellular delivery (2023, March 6)
retrieved 8 March 2023
from https://phys.org/news/2023-03-light-induced-intracellular-delivery.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



TAGGED: acceleration, delivery, intracellular, Lightinduced

Sign Up For Daily Newsletter

Be keep up! Get the latest breaking news delivered straight to your inbox.
[mc4wp_form]
By signing up, you agree to our Terms of Use and acknowledge the data practices in our Privacy Policy. You may unsubscribe at any time.
Aimee Daly March 6, 2023
Share this Article
Facebook Twitter Email Copy Link Print
Leave a comment Leave a comment

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

SUBSCRIBE NOW

Subscribe to our newsletter to get our newest articles instantly!

[mc4wp_form]

HOT NEWS

SpaceX launches Inmarsat I-6 F2 on 12th mission of 2023

Space Flight
February 17, 2023

Is that this black gap jet making stars explode?

Again to Article Listing Greater than twice the anticipated quantity of novae have been discovered…

October 27, 2024

NASA Says Spacecraft Crash Test Successfully Changes Asteroid’s Orbit

CAPE CANAVERAL, Fla. (AP) — A spacecraft that plowed into a small, harmless asteroid millions…

October 11, 2022

World-Saving Spacecraft Passes Test

NASA says its DART spacecraft successfully shifted the path of an asteroid. For us earthlings,…

October 11, 2022

YOU MAY ALSO LIKE

Staff develops transistors with sliding ferroelectricity based mostly on polarity-switchable molybdenum disulfide

Credit score: Yang et al. (Nature Electronics, 2023). Over the previous few years, engineers have been making an attempt to…

Technology
December 23, 2023

Unimolecular self-assembled hemicyanine-oleic acid conjugate acts to eradicate most cancers stem cells: Research

Schematic illustration of unimolecular self-assembled CyOA NPs enhanced phototoxicity to CSCs by implementing oxygen-economical PDT. Credit score: Analysis Most cancers…

Technology
December 22, 2023

Nanotechnology approaches for creating biodeterioration-resistant wooden

chematic illustration of methods utilized for growth of biodeterioration-resistant wooden. Credit score: Ayyoob Arpanaei a,*, Qiliang Fu a,b, Tripti Singh…

Technology
December 21, 2023

Scientists create chiral polyoxometalate-based frameworks with enhanced stability and catalytic exercise

The chiral POM-based frameworks have enhanced stability, chiral catalysis, chiral separation, and proton conductivity. Credit score: Polyoxometalates, Tsinghua College Press…

Technology
December 21, 2023
We use our own and third-party cookies to improve our services, personalise your advertising and remember your preferences.
  • Jobs Board
  • About Us
  • Contact Us
  • Privacy Policy
  • Exclusives
  • Learn How
  • Support
  • Solutions
  • Terms And Conditions
  • Editorial Policy
  • Marketing Solutions
  • Industry Intelligence

Follow US: 

Space Science Digital

Welcome to spacescience.digital, A source for the latest news and developments in the exciting field of space science. Our blog covers a wide range of topics, from the latest space missions and discoveries to updates on technology and scientific breakthroughs. We are passionate about sharing the wonders of the universe with our readers and providing them with engaging and informative content. Join us on this fascinating journey as we explore the mysteries of space and the frontiers of human knowledge.

© 2024 Space Science Digital. All Rights Reserved.

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?